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The Analytical Scientist / Issues / 2026 / March / The Secret Life of a Solvent
Environmental Sample Preparation Mass Spectrometry Spectroscopy Gas Chromatography Liquid Chromatography Chromatography

The Secret Life of a Solvent

Analytical chemistry’s first dedicated solvent guide suggests that greenness is about navigating inevitable trade-offs with greater responsibility – not chasing a mythical “green” label

By James Strachan 03/24/2026 6 min read
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Clinical Scorecard: The Secret Life of a Solvent

At a Glance

CategoryDetail
ConditionSolvent selection in analytical chemistry
Key MechanismsLife-cycle evaluation of solvents including production, use, and waste phases
Target PopulationAnalysts in laboratories worldwide
Care SettingAnalytical chemistry laboratories

Key Highlights

  • GreenSOL provides a comprehensive solvent selection guide for analytical chemistry.
  • The guide evaluates solvents based on their full life cycle from production to disposal.
  • Includes deuterated solvents essential for techniques like NMR.
  • Addresses the cumulative impact of solvent use in diffuse laboratory settings.
  • Aims to empower analysts with tools for greener solvent choices.

Guideline-Based Recommendations

Diagnosis

  • Identify solvents based on their life-cycle impact.

Management

  • Utilize GreenSOL to select solvents with favorable environmental profiles.

Monitoring & Follow-up

  • Assess the environmental impact and treatment potential of solvents.

Risks

  • Consider physical and health hazards associated with solvent use.

Patient & Prescribing Data

Analytical chemists and laboratory analysts

Focus on minimizing environmental and health risks through informed solvent selection.

Clinical Best Practices

  • Adopt a life-cycle perspective when selecting solvents.
  • Ensure broad coverage of solvent classes and properties.
  • Avoid redundant penalization for solvent characteristics in scoring.

References

  • GreenSOL Solvent Selection Guide

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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About the Author(s)

James Strachan

Over the course of my Biomedical Sciences degree it dawned on me that my goal of becoming a scientist didn’t quite mesh with my lack of affinity for lab work. Thinking on my decision to pursue biology rather than English at age 15 – despite an aptitude for the latter – I realized that science writing was a way to combine what I loved with what I was good at. From there I set out to gather as much freelancing experience as I could, spending 2 years developing scientific content for International Innovation, before completing an MSc in Science Communication. After gaining invaluable experience in supporting the communications efforts of CERN and IN-PART, I joined Texere – where I am focused on producing consistently engaging, cutting-edge and innovative content for our specialist audiences around the world.

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