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The Analytical Scientist / Issues / 2026 / March / The Secret Life of a Solvent
Environmental Sample Preparation Mass Spectrometry Spectroscopy Gas Chromatography Liquid Chromatography Chromatography

The Secret Life of a Solvent

Analytical chemistry’s first dedicated solvent guide suggests that greenness is about navigating inevitable trade-offs with greater responsibility – not chasing a mythical “green” label

By James Strachan 03/24/2026 6 min read
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Clinical Report: The Secret Life of a Solvent

Overview

This report discusses the development of GreenSOL, a solvent selection guide aimed at improving the environmental impact of solvents used in analytical chemistry. It emphasizes the importance of a life-cycle perspective in solvent selection to avoid misleading assessments of greenness.

Background

The use of solvents in analytical chemistry has significant environmental and health implications, as many commonly used solvents are derived from non-renewable resources and can be toxic. Traditional solvent selection methods often overlook the full life-cycle impact of solvents, leading to an incomplete understanding of their environmental footprint. The introduction of GreenSOL aims to address these gaps and promote greener practices in analytical laboratories.

Data Highlights

GreenSOL includes a comprehensive evaluation of 58 solvents, considering their production, use, and disposal phases.

Key Findings

  • GreenSOL is the first solvent selection guide specifically tailored for analytical chemistry.
  • The guide includes deuterated solvents, which are crucial for techniques like NMR.
  • Solvent use in analytical labs is highly diffuse, contributing significantly to overall solvent waste.
  • Data availability was a challenge in developing the solvent list, impacting the final assessment.
  • The scoring system evaluates solvents based on a three-phase life-cycle approach: production, laboratory use, and waste.

Clinical Implications

Analysts should consider the full life-cycle impact of solvents when making selections to enhance sustainability in their workflows. Utilizing tools like GreenSOL can help inform better choices that align with regulatory pressures and environmental goals.

Conclusion

The development of GreenSOL represents a significant step towards promoting greener practices in analytical chemistry by providing a comprehensive evaluation of solvents. This guide empowers analysts to make informed decisions that consider the entire life cycle of solvents.

References

  1. Psillakis E., Technical University of Crete, 2023 -- The Secret Life of a Solvent
  2. the medicine maker — Solving the Problem of Insolubility: Part II
  3. the medicine maker — Solving the Problem of Insolubility: Part I
  4. the analytical scientist — State-of-the-Art Sample Preparation Roundtable: Part Two
  5. the analytical scientist — Simplifying Explosives Analysis for Evolving Soil Regulations
  6. ICH Q3C (R9) Guideline on impurities: guideline for residual solvents_Step 5
  7. Solving the Problem of Insolubility: Part II
  8. State-of-the-Art Sample Preparation Roundtable: Part Two
  9. TABLE OF CONTENTS:
  10. Ambient Trichloroethylene Exposure and Parkinson Disease Risk in Medicare Beneficiaries - PubMed

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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About the Author(s)

James Strachan

Over the course of my Biomedical Sciences degree it dawned on me that my goal of becoming a scientist didn’t quite mesh with my lack of affinity for lab work. Thinking on my decision to pursue biology rather than English at age 15 – despite an aptitude for the latter – I realized that science writing was a way to combine what I loved with what I was good at. From there I set out to gather as much freelancing experience as I could, spending 2 years developing scientific content for International Innovation, before completing an MSc in Science Communication. After gaining invaluable experience in supporting the communications efforts of CERN and IN-PART, I joined Texere – where I am focused on producing consistently engaging, cutting-edge and innovative content for our specialist audiences around the world.

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