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The Analytical Scientist / Issues / 2026 / January / Scientists Extract Genomes from 1930s Tumors
Clinical Genomics & DNA Analysis

Scientists Extract Genomes from 1930s Tumors 

A modified ancient DNA workflow reveals genetic and microbial clues hidden in decades-old FFPE blocks  

01/20/2026 2 min read
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Top Institutions in Molecular Pathology and Cancer Genomics

Leading institutions combine expertise in molecular pathology, ancient DNA techniques, cancer genomics, and bioinformatics to optimize DNA extraction from degraded archival specimens and apply advanced sequencing and computational methods to reconstruct and analyze fragmented DNA.

  • #1

    University of Chicago

    Chicago, IL

    Pioneers in adapting ancient DNA methodologies to recover genomic data from archival FFPE tumor samples, enabling novel insights into historical cancer biology and microbiome shifts over nearly a century.

    Key Differentiators

    • Molecular Pathology
    • Cancer Genomics
    • Ancient DNA Techniques
  • #2

    Memorial Sloan Kettering Cancer Center

    New York, NY

    Leads in cancer genomic research with extensive experience in sequencing FFPE samples and integrating genomic data with clinical outcomes, supporting historical and contemporary cancer studies.

    Key Differentiators

    • Cancer Genomics
    • Molecular Pathology
    • Bioinformatics
  • #3

    Broad Institute of MIT and Harvard

    Cambridge, MA

    World-renowned for genomic technology development and large-scale cancer genome projects, with capabilities in handling degraded DNA and reconstructing complex genomic data.

    Key Differentiators

    • Genomics
    • Bioinformatics
    • Cancer Research
  • #4

    Johns Hopkins University

    Baltimore, MD

    Combines expertise in cancer pathology and microbiome studies, contributing to understanding microbial influences on tumor biology using archival specimens.

    Key Differentiators

    • Molecular Pathology
    • Cancer Biology
    • Microbiome Research
  • #5

    University of California, San Francisco (UCSF)

    San Francisco, CA

    Known for integrating molecular pathology with advanced genomic and bioinformatics approaches to study cancer evolution and archival tissue analysis.

    Key Differentiators

    • Cancer Genomics
    • Molecular Pathology
    • Bioinformatics

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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