5 Key Takeaways

• 1

  In 451 children from a French cohort, six PFAS were detected in 93% to 100% of serum samples.

• 2

  Across the cohort, higher perfluoroundecanoic acid concentrations were associated with higher total and LDL cholesterol.

• 3

  Among pre-menarcheal girls, perfluorohexane sulfonate and the combined PFAS mixture were associated with higher total and LDL cholesterol.

• 4

  Among early-pubertal boys, perfluorononanoic acid and perfluorodecanoic acid were associated with higher triglycerides; among postpubertal boys, perfluorooctane sulfonate was associated with lower tri

• 5

  Because PFAS and metabolic markers were measured at the same time, the study could not establish causality or determine whether lipid differences persist into adulthood.