Clinical Scorecard: PFAS Linked to Lipid Changes in Children

At a Glance

Key Highlights

• Six PFAS were detected in 93% to 100% of participants’ serum samples.
• Across the cohort, higher perfluoroundecanoic acid concentrations were associated with higher total and LDL cholesterol.
• Among pre-menarcheal girls, perfluorohexane sulfonate and the combined PFAS mixture were associated with higher total and LDL cholesterol.
• Among boys in early puberty, perfluorononanoic acid and perfluorodecanoic acid were associated with higher triglycerides; among postpubertal boys, perfluorooctane sulfonate was associated with lower triglycerides.
• PFAS and metabolic markers were measured at the same time, so the researchers could not determine cause and effect. The study did not examine whether marker differences persist into adulthood.

Guideline-Based Recommendations

Diagnosis

Management

Monitoring & Follow-up

Risks

Patient & Prescribing Data

451 children from the PELAGIE mother-child cohort in Brittany, France; median age 12.8 years, and 86% had a BMI within the normal range.

No treatment or prescribing intervention was studied. The authors called for longitudinal studies with repeated exposure and metabolic measurements.

Clinical Best Practices

Related Resources & Content