Clinical Scorecard: Taming “The Monster” – with Koen Sandra

At a Glance

Key Highlights

• Focus on complex biotherapeutics including antibody-oligonucleotide conjugates and their analytical challenges.

Guideline-Based Recommendations

Diagnosis

• Consider molecular characterization techniques for accurate diagnosis.

Management

• Implement integrated analytical workflows for managing complex biotherapeutics.

Monitoring & Follow-up

• Regularly assess the stability and efficacy of biopharmaceuticals using advanced analytics.

Risks

• Identify potential analytical pitfalls in characterizing novel biotherapeutics.

Patient & Prescribing Data

Patients receiving biopharmaceutical therapies requiring complex analytical characterization.

Clinical Best Practices

• Utilize orthogonal, high-resolution analytics for complex molecules, such as LC-MS and NMR.
• Consolidate multiple assays into single platforms for efficiency, improving throughput and reducing costs.
• Engage in continuous knowledge sharing and collaboration among scientists to foster innovation.

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