5 Key Takeaways

• 1

  Researchers developed SDR-seq, a single-cell multiomic sequencing platform for simultaneous DNA and RNA analysis.

• 2

  SDR-seq correlates genetic variants with gene expression, addressing challenges in linking genotype to phenotype.

• 3

  The method profiles up to 480 genomic loci and gene expression per cell, providing zygosity data and transcriptomic landscapes.

• 4

  In B cell lymphoma samples, SDR-seq linked mutational burden to gene expression signatures related to tumor behavior.

• 5

  SDR-seq may enhance understanding of disease mechanisms and improve diagnostic strategies for variants of uncertain significance.