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The Analytical Scientist / Issues / 2026 / March / Accelerating Sample Prep The Case for Automation
Sample Preparation Technology Innovation

Accelerating Sample Prep: The Case for Automation 

Manual sample preparation remains a major bottleneck that automation is now beginning to resolve

By Andrew Minett 03/19/2026 3 min read
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Clinical Report: Accelerating Sample Prep: The Case for Automation

Overview

Automation in sample preparation significantly enhances efficiency and reproducibility in analytical workflows. By reducing manual variability and streamlining complex protocols, laboratories can achieve more accurate results, particularly in high-throughput environments.

Background

Sample preparation is a critical step in analytical chemistry, influencing the accuracy of techniques like GC-MS and LC-MS. Traditional manual workflows are labor-intensive and prone to human error, creating bottlenecks in laboratory operations. As the demand for precise and rapid analysis increases, the need for automation becomes essential to meet regulatory standards and improve throughput.

Data Highlights

No specific numerical data provided in the article.

Key Findings

  • Manual sample preparation is slow and difficult to standardize, leading to variability in results.
  • Automation can streamline complex workflows, reducing hands-on time and improving reproducibility.
  • Modern automated systems can handle multiple sample formats and maintain accuracy at trace levels.
  • Laboratories adopting automation report improved throughput and reduced technician workload.
  • Next-generation automation aligns with sustainability goals, reducing solvent consumption and reagent use.

Clinical Implications

Implementing automated sample preparation can significantly enhance laboratory efficiency and accuracy, particularly in high-volume testing scenarios. Laboratories should consider adopting comprehensive automation solutions to meet increasing analytical demands and regulatory requirements.

Conclusion

The shift towards automated sample preparation represents a crucial advancement in analytical chemistry, addressing current workflow challenges and enhancing the reliability of results. As automation technologies evolve, they will play a pivotal role in the future of laboratory practices.

References

  1. the analytical scientist, State-of-the-Art Sample Preparation Roundtable: Part One, 2026 -- Highlights on innovation in sample preparation
  2. the analytical scientist, Five Tips for Optimizing Genomics Workflows, 2026 -- Insights on liquid handling in genomics
  3. the analytical scientist, State-of-the-Art Sample Preparation Roundtable: Part Two, 2026 -- Discussion on sustainable analysis
  4. ISO 15189:2022, 2022 -- Standards for laboratory accreditation and sample preparation
  5. CAP Puts Patient Safety and Regulatory Clarity at the Forefront with New Laboratory Checklist, 2023 -- Emphasis on pre-analytical processes
  6. the analytical scientist — State-of-the-Art Sample Preparation Roundtable: Part Three
  7. ISO 15189:2022 - ISO 15189:2022
  8. CAP Puts Patient Safety and Regulatory Clarity at the Forefront with New Laboratory Checklist
  9. Recommendations from the IFCC Working Group on Laboratory...
  10. C62 | Liquid Chromatography-Mass Spectrometry Methods
  11. Comparison of six serum analyte workflows using routine l...
  12. Analytical performance of an automated LC-MS/MS analyzer for determination of vitamin D concentration in blood plasma and serum
  13. Impact of an autonomous delivery robot on sample turnaround time in a clinical laboratory: an early evaluation of first implementation
  14. Clinical Proteomics
  15. Zainab Jaffar Al Hammad
  16. P A D O 7th EFLM CONFERENCE ON PREANALYTICAL PH
  17. Roche's Mass Spectrometry Steroid Assays Receive FDA Moderate Complexity Designation | Clinical Lab Products
  18. Labcorp Collaborates with Roche to Bring Fully Automated Mass Spectrometry to U.S. Clinical Labs | Labcorp

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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References

  1. DAV Medina et al., “Modern automated sample preparation for the determination of organic compounds: A review on robotic and on-flow systems,” Trends in Analytical Chemistry, 166, 117171 (2023).
  2. WA Khan et al., “Automation and high throughput sample analysis with various platforms in microextraction techniques: A need for ecofriendly, green, and cost-effective sample preparation approaches – A review,” Trends in Analytical Chemistry, 189, 118247 (2025).

About the Author(s)

Andrew Minett

Technical Director at ePrep

More Articles by Andrew Minett

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