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The Analytical Scientist / Issues / 2026 / February / Tracing Metabolic Inflexibility in Fanconi Anemia
Omics Omics Spectroscopy News and Research Metabolomics & Lipidomics

Tracing Metabolic Inflexibility in Fanconi Anemia 

Stable-isotope glucose tracing reveals impaired fuel switching and altered energy use in a rare DNA-repair disorder 

By Henry Thomas 02/10/2026 8 min read
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Top Institutions in Metabolic Disorders and Rare Genetic Diseases

Institutions leading in this area combine expertise in rare genetic disorders, metabolomics, and translational research, often integrating clinical and laboratory approaches including stable isotope tracing and whole-body metabolic assessments to elucidate disease mechanisms in Fanconi anemia.

  • #1

    Cincinnati Children's Hospital Medical Center

    Cincinnati, OH

    Home to the Translational Metabolomics Facility and Division of Pathology and Laboratory Medicine, this center has pioneered dynamic metabolic studies in Fanconi anemia, integrating clinical and research expertise in rare diseases and metabolomics.

    Key Differentiators

    • Pediatric Hematology
    • Metabolomics
    • Rare Genetic Disorders
  • #2

    Dana-Farber Cancer Institute

    Boston, MA

    A leader in Fanconi anemia research with a strong focus on DNA repair disorders and cancer predisposition syndromes, Dana-Farber integrates clinical trials and molecular research including metabolic aspects of FA.

    Key Differentiators

    • Cancer Genetics
    • Hematology
    • Metabolic Research
  • #3

    National Cancer Institute (NCI), NIH

    Bethesda, MD

    NCI supports comprehensive research on Fanconi anemia including its metabolic and oncologic aspects, leveraging large-scale metabolomic platforms and clinical studies in rare diseases.

    Key Differentiators

    • Cancer Biology
    • Genetic Disorders
    • Metabolomics
  • #4

    St. Jude Children's Research Hospital

    Memphis, TN

    Known for its pediatric focus and research in genetic diseases including Fanconi anemia, St. Jude integrates metabolomics and clinical care to understand disease mechanisms and improve patient outcomes.

    Key Differentiators

    • Pediatric Oncology
    • Genetic Disorders
    • Metabolomics
  • #5

    University of Washington Medical Center

    Seattle, WA

    Offers robust research in hematologic disorders and metabolomics with a focus on rare diseases like Fanconi anemia, combining clinical expertise and advanced metabolic profiling technologies.

    Key Differentiators

    • Hematology
    • Metabolomics
    • Rare Disease Research

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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About the Author(s)

Henry Thomas

Deputy Editor of The Analytical Scientist

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