The Analytical Scientist / Issues / 2013 / Sep

Sep

Fields & Applications

A toolbox of amino acids for mAb separations

September 12, 2013

Size exclusion chromatography (SEC) is well established for mAb aggregate analysis. As the technique has been used since the early days of monoclonal antibody (mAb) development for pharmaceutical purposes, various method improvements have evolved. For instance, the benefits of arginine on analytical SEC of mAb aggregate samples are well-known. A new application note shows how SEC of mAb aggregate samples may take advantage of other amino acid additives in the mobile phase.

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A toolbox of amino acids for mAb separations (1)
Techniques & Tools

The Origins of Mass Spectrometry

September 9, 2013

Between 1900 and 1940, the development of the positive ray analyzer led to the study of isotopes for the first time, setting the stage for the development of mass spectrometry. Here, a series of brilliant experiments from the “Era of the Physicist” is revisited.

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The Origins of Mass Spectrometry
Fields & Applications Sponsored

Determination of phthalates in water using the VWR-Hitachi ChromasterUltra Rs high-resolution column

September 9, 2013

The ChromasterUltra Rs together with LaChrom Ultra II high resolution column delivers excellent performance for the separation of similar compounds.

1 min read

Determination of phthalates in water using the VWR-Hitachi ChromasterUltra Rs high-resolution column
Techniques & Tools

We Are Family

September 9, 2013

Sitting Down With Alexandra Knauer, Owner, and Alexander Buenz, CEO, of Knauer.

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We Are Family
Techniques & Tools

Tracking Designer Drugs

September 9, 2013

Combining solid phase extraction with high-resolution accurate mass LC-MS increases sample throughput and improves detection and identification of novel synthetic cannabinoids.

1 min read

Tracking Designer Drugs
Fields & Applications

Personalized Patents

September 9, 2013

As medicine advances towards analyzing patient biomarkers to predict response to specific drugs, the centuries-old European patent system is adapting to keep pace.

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Personalized Patents
Fields & Applications

Towards Tsunami-Resistant Chemometrics

September 9, 2013

Despite a fall from grace in recent years, chemometrics has a key role to play in the interpretation of mega-variate datasets. Here, I diagnose the problems that the field currently faces and propose that developing a theory of chemometrics offers a way forward.

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Towards Tsunami-Resistant Chemometrics
Techniques & Tools

Omega-3 Odyssey

September 9, 2013

Are the health claims for these compounds warranted and, if so, can their measurement be streamlined?

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Omega-3 Odyssey
Fields & Applications

Ears Wide Open

September 6, 2013

The best clinical diagnostic tools must balance accuracy with cost and ease-of-use. Listen, and get a full understanding of the needs in your field: it’s not just about the science.

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Ears Wide Open
Techniques & Tools

Multi-dimensional Marvel

September 6, 2013

GC×GC provides simple improvements today and will be key to the personalized miniature measurement devices of tomorrow

1 min read

Multi-dimensional Marvel

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