Fields & Applications Pharma & Biopharma

Fast Analysis of IgG Charge Heterogeneity by Ion Exchange Chromatography

Evaluation of strong and weak cation exchange columns and dependence of separation on mobile phase pH

09/24/2014

sponsored by Tosoh

Therapeutic antibodies are enjoying high growth rates in the pharmaceutical market. In 2013, 7 of the top ten best-selling global drug brands were monoclonal antibodies (mAbs). The main product characteristics to be analyzed in process monitoring and quality control are aggregation, fragmentation, glycosylation and charge heterogeneity. We present the fast analysis of mAb charge heterogeneity by cation exchange chromatography on TSKgel STAT columns.

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